1. Zendesk: Zendesk is a market leader when it comes to help desk ticketing systems. It boasts a user-friendly interface and robust features that allow businesses to manage and prioritize customer queries effectively. Its customization options make it an excellent choice for businesses of all sizes.

2. Freshdesk: Freshdesk offers an intuitive and feature-rich solution for managing customer tickets seamlessly. It supports multi-channel communication, customizable SLA policies, and automated workflows. With its affordable pricing, Freshdesk caters to businesses of various sizes.

3. ServiceNow: ServiceNow is known for its advanced IT service management (ITSM) capabilities, making it an ideal choice for large enterprises with complex IT infrastructures or organizations in regulated industries. It offers powerful reporting, customizable dashboards, and automation tools that enhance customer support management.

4. Jira Service Management: Jira Service Management is a versatile platform built upon Atlassian’s popular Jira software. Its impressive array of integrations and customization options make it a great choice for teams using other Atlassian products or those looking to create a unified ecosystem for their service processes.

5. HelpScout: HelpScout provides a shared inbox solution designed specifically for smaller teams and startups. It places a strong emphasis on personalization and collaboration while still offering powerful features such as automated workflows and reporting that you would expect from an effective ticketing system.

6. Zoho Desk: Zoho Desk is a powerful help desk solution with easy-to-use ticket management features, automation capabilities, and reporting tools that make it suitable for businesses of all sizes. Its affordability makes it popular among SMBs.

7. HappyFox: HappyFox offers a comprehensive set of help desk features suitable for businesses across different industries. Its smart rules engine helps streamline ticket management by automating repetitive tasks, while its advanced analytics provide valuable insights into your customer support performance.

8. Kayako: Kayako is a customer support platform designed for businesses of all sizes. It combines advanced ticketing, live chat, self-service, and customer engagement features, resulting in an all-in-one help desk solution that can easily integrate with your existing tools and processes.

9. Intercom: Intercom is a powerful communication platform that combines live chat functionality with a help desk ticketing system. Its proactive messaging features and user tracking capabilities allow you to engage with customers proactively and provide personalized support experiences.

10. ConnectWise Manage: ConnectWise Manage is an ideal solution for managed service providers (MSPs) and organizations with complex IT systems. It offers an organized workflow management system to handle tickets effectively, while its automation capabilities help reduce response time.

11. Autotask: Autotask is another popular choice among MSPs for managing customer support requests. It provides sophisticated ticket management tools, contract management features, and a customizable dashboard, allowing you to keep track of your organization’s support performance in real-time.

In conclusion, the 11 best help desk ticketing systems mentioned above cater to different business sizes and requirements. Choosing the right one depends on your organization’s unique needs and goals for streamlining customer support operations.