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Best of the Best Lists
Home›Best of the Best Lists›The 9 Best Headache Medicines

The 9 Best Headache Medicines

By Matthew Lynch
September 1, 2023
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Headaches can be painful, annoying, and disruptive to daily life, but finding the right headache medicine can provide much-needed relief. Here is a list of the nine best headache medicines available for different types of headaches.

1. Ibuprofen (Advil, Motrin)

Ibuprofen is a popular over-the-counter (OTC) nonsteroidal anti-inflammatory drug (NSAID) that works by reducing inflammation, which in turn provides relief from headache pain. It is effective for treating tension headaches and migraines.

2. Aspirin (Bayer, Excedrin)

Aspirin is another OTC NSAID and a common choice for headache relief. Not only does it alleviate pain, but it also has anti-inflammatory properties. It’s especially useful for treating migraine and tension headaches.

3. Naproxen (Aleve)

Naproxen is an OTC NSAID that provides long-lasting relief for headache pain. It’s beneficial for those suffering from severe headaches, as its effects can last up to 12 hours.

4. Acetaminophen (Tylenol)

Acetaminophen is an OTC analgesic that effectively relieves mild to moderate headache pain. It lacks anti inflammatory properties but is suitable for use by people who are allergic to or intolerant of NSAIDs.

5. Excedrin Migraine

Excedrin Migraine is a combination drug containing aspirin, acetaminophen, and caffeine – ingredients specifically designed to alleviate migraine symptoms such as sensitivity to light and sound, nausea, and pain.

6. Sumatriptan (Imitrex)

Sumatriptan is a prescription medication belonging to the triptan class of drugs designed specifically to treat migraines. These drugs work by constricting blood vessels in the brain and are most effective when taken at the first sign of a migraine.

7. Fioricet

Fioricet is a prescription medication that combines acetaminophen, butalbital (a barbiturate), and caffeine to provide relief from tension headaches. However, it has the potential to be habit-forming, so it should be used cautiously and under medical supervision.

8. Propranolol (Inderal)

Propranolol is a prescription beta-blocker medication primarily used as a preventive treatment for migraines, tension headaches, and cluster headaches. It works by reducing blood pressure and heart rate to combat the causes of headache pain.

9. Amitriptyline (Elavil)

Amitriptyline is an antidepressant prescription medication that has been found to be effective in preventing migraines and tension headaches when taken in low doses. It works by regulating serotonin levels in the brain, which helps reduce the frequency and intensity of headache pain.

When choosing a headache medicine, consider the type of headache you’re experiencing, your personal health history, any potential drug interactions, and consult with your healthcare provider for guidance. With so many options available, you can find relief from your headache pain and get back to your daily routine more quickly.

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